At this time of year everyone celebrates warmth and good cheer.
We're adding your achievements.

As the temperature starts to dip, and you start preparing for the holiday season, we wanted to take a quick glimpse back at a few of the amazing accomplishments over the past year. For membrane protein structural biologists, 2018 has certainly been a record breaking year! Over 100 unique membrane protein structures have been deposited this year, with nearly half determined using Cryo-EM. We are delighted that our tools have contributed to these successes including:
  • The increasing use of GDN, which has been used in the Cryo-EM structure determination of over 10 proteins this year, including the recent structures of the TRPV3(1), TRPM2(2), and Nav1.4(3) ion channels, as well as the structure of an intact bacterial ATP synthase(4).
  • The growing use of Amphipol PMAL-C8 which has been instrumental in the Cryo-EM structure determination of a number of membrane proteins. These include TRPM7(5), PKD2L1(6), the Mitochondrial calcium uniporter(7), and NBCe1 transporter(8).
  • The use of Crystallophore #1 to crystallize and phase the structure of the Vitamin B12 transporter BtuM(9). This is the first published example of the use of Crystallophore on a membrane protein.
Together, Anatrace and Molecular Dimensions have had an equally exciting year as well. Our Crystallization Screen Redundancy Poster has been incredibly popular, and we’re delighted every time we see a copy hanging in a lab.  Don’t have one?  You can still request a copy here.  We also announced the exciting news that two new companies, ProteinArk and BioServUK, have joined our roster, allowing us to support all aspects of your protein research even further. Lastly, both Anatrace and Molecular Dimensions have been busy developing new and innovative products this past year, including:
  • Diisobutylene Maleic Acid (DIBMA) – Our first foray into the SMALP field. DIBMA allows for the direct solubilization and purification of membrane proteins from the native lipid bilayer.
  • MemChannel, MemTrans, and MemGoldMeso – Three new screens for the crystallization of membrane proteins.
  • LMNG:CHS Premixed Solution – LMNG mixed with CHS is one of the most commonly used detergents for the solubilization of membrane proteins. Our premixed detergent solutions allow you to increase reproducibility and save time.
  • Morpheus III – The latest addition to the Morpheus family, this screen contains a range of small, drug-like compounds to aid protein stabilization and crystallization.
  • Premixed Monoolein:Cholesterol for LCP – Cholesterol is often used as an additive for LCP crystallization, especially for GPCRs. This mixture can be used directly for LCP experiments – no more dissolving lipids in chloroform and worrying if all of the solvent is removed.
  • Ligand Friendly Screen (LFS) – Developed by the Structural Genomics Consortium (SGC) in Oxford, this crystallization screen is designed to produce crystals that are directly usable for compound binding studies.

We want to thank you for your business and wish you a healthy and prosperous 2019!

To spread a little holiday cheer, we want to remind you of two ongoing promotions we have until the end of the year:
  • We are offering a 5% discount on either our 1 gram or 5 gram pack sizes of GDN (promo code: TRYGDN), a 5% discount on 2 x 25 gm bottles of GDN, or a 10% discount on 4 x 25 gram bottles of GDN (promo code: BULKGDN)
  • Molecular Dimensions is offering a 40% discount on Morpheus Complete, a three screen bundle containing Morpheus I, II, and III.

References:
  1. Singh, A. K., et al. (2018) Nat Struct Mol Biol. 25(9), 805-813.
  2. Huang, Y., et al. (2018) Nature 562(7725), 145-149.
  3. Pan, X., et al. (2018) Science 362(6412). pii: eaau2486. doi: 10.1126/science.aau2486. Epub 2018 Sep 6.
  4. Guo, H. and Suzuki, T., BioRxiv preprint, doi:https://doi.org/10.1101/463968.
  5. Duan, J., et al. (2018) Proc. Natl Acad Sci U S A 115(35), E8201-E8210. doi: 10.1073/pnas.1810719115. Epub 2018 Aug 14.
  6. Hulse, R. E., et al. (2018) Elife, pii: e36931. doi: 10.7554/eLife.36931.
  7. Yoo, J. et al. (2018) Science 361(6401), 506-511.
  8. Huynh, K. W., et al. (2018) Nat Commun. 9(1), 900.
  9. Rempel, S., et al. (2018) Nat Commun. 9(1), 3038.